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Lysine acetylsalicylate/Metoclopramide hydrochloride shouldn't be suitable for everybody and some folks should never use it. The exception to the rule is the DOT1 household, members of which methylate K79 in the globular area of histone H3 and which are structurally not associated to SET-area proteins 4 - 6 Recent work means that SET-area-containing proteins methylate a number of proteins in addition to histones (see later)